Syntheses of Benzothiazinophenothiazine Derivatives and Evaluation of their Antimicrobial Activities. ABSTRACT The syntheses of benzothiazinophenothiazine derivatives from simple heterocyclic compounds as precursors is described. Condensation of 2-aminothiophenol with 2,3-dichloro-1,4-naphthoquinone in an alkaline medium furnished a good yield of the intermediate, 6-chloro-5H-benzo[a]phenothiazin-5- one. Further condensation of the intermediate with 2,4-diamino-6-hydroxypyrimidine-5-thiol obtained by alkaline hydrolysis of 2,4-diamino-6-hydroxy-5-thiacyanatopyrimidine […]
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Source: cs