Syntheses of Benzothiazinophenothiazine Derivatives and Evaluation of their Antimicrobial Activities

Syntheses of Benzothiazinophenothiazine Derivatives and Evaluation of their Antimicrobial Activities. ABSTRACT The syntheses of benzothiazinophenothiazine derivatives from simple heterocyclic compounds as precursors is described. Condensation of 2-aminothiophenol with 2,3-dichloro-1,4-naphthoquinone in an alkaline medium furnished a good yield of the intermediate, 6-chloro-5H-benzo[a]phenothiazin-5- one. Further condensation of the intermediate with 2,4-diamino-6-hydroxypyrimidine-5-thiol obtained by alkaline hydrolysis of 2,4-diamino-6-hydroxy-5-thiacyanatopyrimidine […]

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Source: cs